منابع مشابه
Grapefruit juice-drug interactions.
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine ...
متن کاملManagement of grapefruit-drug interactions.
Grapefruit is a healthy addition to a well-balanced diet. However, the fruit has been shown to affect the metabolism of many medications, increasing the risk of toxicity and adverse effects. Characteristics of oral medications that may interact with grapefruit include extensive metabolism through the intestinal cytochrome P450 3A4 system, low bioavailability, and a narrow therapeutic index. Pro...
متن کاملCompetitiveness of the Spanish and Dutch Greenhouse Industries With the Florida Fresh Vegetable Industry1
1. This document is HS918, one of a series of the Horticultural Sciences Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Publication date: May 2003. Please visit the EDIS Web site at http://edis.ifas.ufl.edu. 2. Daniel J. Cantliffe, professor and chair, Horticultural Sciences Department; John J. Vansickle, professor, Food an...
متن کامل2012 Florida Citrus Pest Management Guide: Management Options for Nonbearing Groves and Fresh or Processed Fruit1
2. L.L. Stelinski, assistant professor, Entomology and Nematology Department; J.H. Graham, professor, Soil and Water Science Department; R.P. Muraro, professor, and R.A. Morris, associate Extension scientist, Food and Resource Economics Department; Citrus REC, Lake Alfred, Florida; Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida, Gainesv...
متن کاملAmounts and variation in grapefruit juice of the main components causing grapefruit-drug interaction.
A method for the determination of three furocoumarins containing two new chemicals (GF-I-1 and GF-I-4) in commercially available grapefruit juice and grapefruit itself was developed using high-performance liquid chromatography (HPLC). These components isolated from grapefruit juice have 5-geranyloxyfurocoumarin dimer structures showing extremely high affinities for a form of cytochrome P450 (CY...
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ژورنال
عنوان ژورنال: EDIS
سال: 1969
ISSN: 2576-0009
DOI: 10.32473/edis-fy277-2002